蒋翔锐

蒋翔锐 

药物化学专业，中国科学院上海药物研究所研究员，硕士生导师。2006年进入上海药物所进行博士后研究工作，出站后留所工作至今。作为骨干人员或主要发明人参与2个1类创新药物TPN729、TPN171的研究开发并获得临床批件。负责多项国家自然科学基金面上项目、“新药创制”国家重大专项、中科院先导专项和药物创新研究院自主部署项目，并参与多项国家863计划、中科院活性天然产物发现评价与转化项目以及上海市科技支撑计划等科研项目。

研究领域： 

小分子构效关系研究、天然产物结构修饰与药物合成工艺研究。主要研究内容为中枢神经系统疾病与心脑血管疾病相关创新药物发现。

代表性论文：

1、Junchi Zhang^#, Fuqiang Zhu, Guanghui Tian, Xiangrui Jiang*, Jingshan Shen, Improved Synthesis of 6-Chloro-5-methylpyridin-2-amine: A Key Intermediate for Making Lumacaftor, https://doi.org/10.1021 /acs.oprd.9b00556.

2、Zhen Wang^#, Xiangrui Jiang^#, Xianglei Zhang^#, Guanghui Tian, Rulei Yang, Jianzhong Wu, Xiaoli Zhou, Zheng Liu, Xiaojun Yang, Chunhui Wu, Jing Shi, Jianfang Li, Jin Suo, Yu Wang, Rongxia Zhang, Zhijian Xu, Xudong Gong, Yang He, Weiliang Zhu, Haji Akber Aisa, Hualiang Jiang*, Yechun Xu*, and Jingshan Shen*. Pharmacokinetic-driven optimization of 4(3H)-pyrimidiones as phosphodiesterase Type 5 inhibitiors leading to TPN171, a clinical candidate for the treatment of pulmonary arterial hypertension, Journal of Medicinal Chemistry, 2019, 62, 4979−4990

3、Jing Xing^#, Rukang Zhang^#, Xiangrui Jiang^#, Tianwen Hu, Xinjun Wang, Gang Qiao, Junjian Wang, Fengling Yang, Xiaomin Luo, Kaixian Chen, Jingshan Shen*, Cheng Luo*, Hualiang Jiang, Mingyue Zheng*, Rational Design of 5-((1H-imidazol-1-yl)methyl)quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors, European Journal of Medicinal Chemistry, 2019, 163, 281−294.

4、Tianwen Hu^#, Feipu Yang, Tao Jiang, Weiming Chen, Jian Zhang, Jianfeng Li, Xiangrui Jiang*, Jingshan Shen, Synthesis of Impurities From Pramipexole Dihydrochloride Tablet, Organic Process Research & Development, 2016，20,1899−1905.

5、Chunhui Wu^#, Weiming Chen, Dehui Jiang, Xiangrui Jiang,* Jingshan Shen An Improved Synthesis of 4-(1-Piperazinyl)benzo[b]thiophene Dihydrochloride, Organic Process Research & Development, 2015, 19, 555−558

其他科研科研成果（专利等）：

1、一类杂环化合物、其制备方法和用途；中国申请号：CN201580008897.5

2、一种酰基氨基吡啶的制备及其用途；公开号：CN2017101885472